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The concomitant usage of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may perhaps cause an increase in methadone plasma concentrations, which could induce perhaps fatal respiratory melancholy. Furthermore, discontinuation of concomitantly used cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may also bring about an increa

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